Why the study?
Circular RNAs act as regulatory targets in atherogenesis, but the biological role and molecular mechanism of circ_0093887 in ox-LDL-induced atherosclerosis of human aortic endothelial cells remained to be researched.
Population
AS patients and ox-LDL-treated HAECs
Comparison
Circ_0093887 overexpression or knockdown vs controls
Design
In vitro laboratory study
Authors
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Hypothesis-generating for atherosclerosis therapy; leaves open translation from cell models to clinical outcomes.
Circ_0093887 protects human aortic endothelial cells from ox-LDL-induced injury by acting as a miR-876-3p sponge to upregulate CCND2 and SUCNR1, suggesting a potential therapeutic target for atherosclerosis.
Gao et al. (2021) studied this question.
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