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January 1, 2021Open MedicineOpen Access

circ_0003204 silencing inhibited ox-LDL-induced HUVEC injury (suppressed apoptosis, inflammatory response, and oxidative stress) via the miR-330-5p/TLR4 axis and NF-κB signaling pathway.

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Why the study?

Circular RNAs play an important role in atherosclerosis progression, but the specific role of circ_0003204 in atherosclerosis remained unclear.

Population

Oxidized low-density lipoprotein-induced human umbilical vein endothelial cells

Comparison

circ_0003204 silencing vs controls

Design

In vitro controlled laboratory study

Authors

QSQiuxia SuXDXianhua DongCTChonghui Tang

Discussion

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Member takes

Overview

Hypothesis-generating for circ_0003204 as an atherosclerosis target; leaves open human translation of the miR-330-5p/TLR4/NF-κB axis.

Structured PICO

P
Population
Oxidized low-density lipoprotein (ox-LDL)-induced human umbilical vein endothelial cells (HUVECs) as an in vitro atherosclerosis model
I
Intervention
Silencing/knockdown of circ_0003204
C
Comparator
ox-LDL induction without circ_0003204 silencing
O
Outcome
Cell viability, apoptosis, inflammatory response, and oxidative stresssurrogate

Knockdown of circ_0003204 protects against ox-LDL-induced endothelial injury by regulating the miR-330-5p/TLR4/NF-κB pathway, highlighting a potential novel target for atherosclerosis.

Cite This Study

Su et al. (2021) studied this question.

synapsesocial.com/papers/6a97e522e2ee2f7f1036671fhttps://doi.org/10.1515/med-2021-0209
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Knockdown of circular RNA hsa_circ_0003204 inhibits oxidative stress and apoptosis through the miR-330-5p/Nod2 axis to ameliorate endothelial cell injury induced by low-density lipoprotein2021 · 13 citations
  2. 2Circular RNA circ_0008896 contributes to oxidized low-density lipoprotein-induced aortic endothelial cell injury via targeting miR-188-3p/NOD2 axis2023 · 6 citations
  3. 3Circ_0093887 upregulates CCND2 and SUCNR1 to inhibit the ox‐LDL‐induced endothelial dysfunction in atherosclerosis by functioning as a miR‐876‐3p sponge2021 · 20 citations
  4. 4Circ_CHMP5 aggravates oxidized low-density lipoprotein-induced damage to human umbilical vein endothelial cells through miR-516b-5p/TGFβR2 axis2023 · 10 citations
  5. 5CIRC_0091822 CONTRIBUTES TO THE PROLIFERATION, INVASION, AND MIGRATION OF VASCULAR SMOOTH MUSCLE CELLS UNDER OXIDIZED LOW-DENSITY LIPOPROTEIN TREATMENT2023 · 1 citations