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December 16, 2025Clinical and Applied Thrombosis/HemostasisOpen Access

miR-3150b-3p Promotes Vascular Smooth Muscle Cell Injury by Targeting ARL5B

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Authors

WWWei WangRLRuirui LiangWWWeimin Wang

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Overview

This research finds that miR-3150b-3p promotes oxidative stress in patients with CHD, suggesting its potential as a diagnostic marker.

Key Points

  • This research aims to investigate the role of miR-3150b-3p in coronary heart disease and its effects on vascular smooth muscle cells.
  • Measured serum miR-3150b-3p in hypertensive and CHD patients using qRT-PCR.
  • Evaluated the diagnostic value of miR-3150b-3p with ROC curve analysis.
  • Induced oxidative stress in HVSMCs with ox-LDL in vitro and assessed cell viability with CCK-8 assay.
  • Measured inflammatory factors and oxidative stress levels using ELISA, superoxide dismutase, and malondialdehyde analysis.
  • Verified the interaction between miR-3150b-3p and ARL5B with luciferase assay.
  • Serum miR-3150b-3p is elevated in CHD patients and correlates with disease severity.
  • Diagnostic value of miR-3150b-3p is confirmed through ROC curve analysis.
  • In vitro miR-3150b-3p inhibitor reduced inflammatory factors and increased superoxide dismutase activity.
  • Malondialdehyde levels decreased in response to the miR-3150b-3p inhibitor.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/6940aca13507a57a7f7a3d37https://doi.org/10.1177/10760296251399647
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Also Consider

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