What is the clinical evidence from this study?

Study design: Case-Control. Population: Acute coronary syndrome (n=193). Intervention: Elevated miR-3615 expression vs. Controls. Primary outcome: Diagnosis of ACS and occurrence of major adverse cardiovascular events (MACE).

What question did this study set out to answer?

This study aims to assess the clinical significance of miR-3615 in acute coronary syndrome (ACS) patients and its role in disease mechanisms.

June 13, 2026Clinical and Applied Thrombosis/HemostasisOpen Access

Upregulation of Serum miRNA-3615 Serves as a Biomarker to Predict Disease Onset and Prognosis in Acute Coronary Syndrome Patients

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Key result

Elevated miR-3615 expression is linked to higher risk of ACS, MACE, and severe coronary lesions.

n=193

Why the study?

Does serum miR-3615 expression serve as a diagnostic and prognostic biomarker in patients with acute coronary syndrome?

Population

121 patients with acute coronary syndrome and 72 controls; in vitro cell model of human coronary artery…

Comparison

Measurement of serum miR-3615 and DPF3… vs Healthy controls; untreated/control HCASMCs

Design

Case-control

Authors

YWYue WangUniversity of Stuttgart WHWeiling HuangYichang Central People's Hospital XTXianwei TianXinxiang Central Hospital

Discussion

Member takes

Implication

Upregulation of serum miR-3615 serves as a potential diagnostic and prognostic biomarker for acute coronary syndrome and promotes pathological changes in coronary smooth muscle cells.

Key Points

This study aims to assess the clinical significance of miR-3615 in acute coronary syndrome (ACS) patients and its role in disease mechanisms.
Included 121 ACS patients and 72 controls; quantified miR-3615 and DPF3 expression using qRT-PCR.
Analyzed clinical diagnostic and prognostic value of miR-3615 with ROC curves and multivariate regression.
Established an in vitro model using human coronary artery smooth muscle cells induced by oxidized low-density lipoprotein for functional studies.
MiR-3615 levels were significantly elevated in ACS patients, especially in those with major adverse cardiovascular events (MACE).
Positive correlation found between miR-3615 levels, Gensini score, and cardiac troponin I (cTnI).
Inhibition of miR-3615 reduced pathological cell proliferation, migration, and inflammation in the HCASMCs model.

Study Design

Type

Case-Control (n=193)

Structured PICO

Does serum miR-3615 expression serve as a diagnostic and prognostic biomarker in patients with acute coronary syndrome?

Population

193 participants, including 121 patients with acute coronary syndrome and 72 controls.

Exposure

Measurement of serum miR-3615 and DPF3 expression; in vitro inhibition of miR-3615

Comparator

Healthy controls; untreated/control HCASMCs

Outcome

Diagnostic and prognostic value of miR-3615 for ACS and major adverse cardiovascular events (MACE)surrogate

Upregulation of serum miR-3615 serves as a potential diagnostic and prognostic biomarker for acute coronary syndrome and promotes pathological changes in coronary smooth muscle cells.

Cite This Study

Wang et al. (2026) conducted a case-control in Acute coronary syndrome (n=193). Elevated miR-3615 expression vs. Controls was evaluated on Diagnosis of ACS and occurrence of major adverse cardiovascular events (MACE). Elevated miR-3615 expression was associated with acute coronary syndrome, major adverse cardiovascular events, and increased coronary lesion severity.

synapsesocial.com/papers/6a2cf688faef96ed7f058353 https://doi.org/10.1177/10760296261456856

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Implication

Upregulation of serum miR-3615 serves as a potential diagnostic and prognostic biomarker for acute coronary syndrome and promotes pathological changes in coronary smooth muscle cells.

Upregulation of Serum miRNA-3615 Serves as a Biomarker to Predict Disease Onset and Prognosis in Acute Coronary Syndrome Patients

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Upregulation of Serum miRNA-3615 Serves as a Biomarker to Predict Disease Onset and Prognosis in Acute Coronary Syndrome Patients

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

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