What does this research mean for the field?

miR-4446-3p is significantly elevated in coronary heart disease, serves as a predictive biomarker for disease occurrence and postoperative major adverse cardiovascular events (MACE), and promotes adverse disease progression by targeting ABCG1 to induce endothelial dysfunction. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the clinical diagnostic and prognostic significance of miR-4446-3p in coronary heart disease and investigate its regulatory role in endothelial dysfunction.

August 23, 2026European journal of medical researchOpen Access

Clinical value and regulatory role of miR-4446-3p in coronary heart disease

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Authors

MCMingli Cui QMQiangqiang Mu JHJinqiu Huo

Discussion

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Overview

Observational and experimental study reveals elevated miR-4446-3p predicts adverse cardiac events and drives endothelial dysfunction in coronary heart disease, highlighting its biomarker utility.

Key Points

To evaluate the clinical diagnostic and prognostic significance of miR-4446-3p in coronary heart disease and investigate its regulatory role in endothelial dysfunction.
Enrolled 103 coronary heart disease (CHD) patients and 91 healthy volunteers, monitoring CHD patients for major adverse cardiovascular events (MACE) over 1 year of follow-up.
Assessed correlations between miR-4446-3p levels, Gensini scores, and myocardial injury biomarkers including cTnI, CK-MB, and NT-proBNP.
Performed in vitro miR-4446-3p knockdown in endothelial cells to evaluate proliferation, apoptosis, inflammation, oxidative stress, and direct targeting of ABCG1.
Circulating miR-4446-3p was significantly elevated in CHD patients and positively correlated with cTnI, CK-MB, NT-proBNP, and Gensini score.
High miR-4446-3p expression demonstrated strong predictive performance for CHD occurrence and postoperative MACE risk.
Knockdown of miR-4446-3p enhanced endothelial proliferation and reduced inflammation and oxidative stress by targeting ABCG1.

Cite This Study

Cui et al. (2026) studied this question.

synapsesocial.com/papers/6a8aad667677a34114445804 https://doi.org/10.1186/s40001-026-05011-6

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August 23, 2026European journal of medical researchOpen Access

Clinical value and regulatory role of miR-4446-3p in coronary heart disease

View Full Paper

Ask AI

Bookmark

Authors

MCMingli Cui QMQiangqiang Mu JHJinqiu Huo

Discussion

Member takes

Overview

Observational and experimental study reveals elevated miR-4446-3p predicts adverse cardiac events and drives endothelial dysfunction in coronary heart disease, highlighting its biomarker utility.

Key Points

To evaluate the clinical diagnostic and prognostic significance of miR-4446-3p in coronary heart disease and investigate its regulatory role in endothelial dysfunction.
Enrolled 103 coronary heart disease (CHD) patients and 91 healthy volunteers, monitoring CHD patients for major adverse cardiovascular events (MACE) over 1 year of follow-up.
Assessed correlations between miR-4446-3p levels, Gensini scores, and myocardial injury biomarkers including cTnI, CK-MB, and NT-proBNP.
Performed in vitro miR-4446-3p knockdown in endothelial cells to evaluate proliferation, apoptosis, inflammation, oxidative stress, and direct targeting of ABCG1.
Circulating miR-4446-3p was significantly elevated in CHD patients and positively correlated with cTnI, CK-MB, NT-proBNP, and Gensini score.
High miR-4446-3p expression demonstrated strong predictive performance for CHD occurrence and postoperative MACE risk.
Knockdown of miR-4446-3p enhanced endothelial proliferation and reduced inflammation and oxidative stress by targeting ABCG1.

Cite This Study

Cui et al. (2026) studied this question.

synapsesocial.com/papers/6a8aad667677a34114445804 https://doi.org/10.1186/s40001-026-05011-6

View Full Paper

Ask AI

Bookmark