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April 10, 2026Journal of Biochemical and Molecular Toxicology

miR‐3613‐3p Is a New Diagnostic Indicator of Acute Coronary Syndrome (ACS) That Reduces Endothelial Damage by Targeting Ring Finger and CCCH‐Type Domains 1 (RC3H1)

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Authors

JLJianfei LiuXWXiangran WeiDCDongsheng Chen

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Overview

Demonstrates miR-3613-3p's potential as a diagnostic biomarker in acute coronary syndrome, suggesting therapeutic avenues to reduce endothelial damage.

Key Points

  • The research investigates the role of miR-3613-3p in diagnosing acute coronary syndrome and its mechanism in endothelial injury.
  • Quantitative real-time polymerase chain reaction (qRT-PCR) for miR-3613-3p expression analysis.
  • Receiver operator characteristic (ROC) curve for diagnostic potential assessment.
  • Correlation analysis between miR-3613-3p and ACS metrics.
  • Cell counting kit-8 (CCK-8) for evaluating cell proliferation in human coronary artery endothelial cells.
  • Dual-luciferase reporter assay to validate the interaction between miR-3613-3p and RC3H1.
  • Serum levels of miR-3613-3p were significantly downregulated in ACS compared to healthy individuals.
  • miR-3613-3p correlated with Gensini score, cardiac troponin I, creatine kinase isoenzyme-MB, and left ventricular ejection fraction.
  • Overexpression of miR-3613-3p in vitro enhanced cell proliferation and reduced inflammatory factor release.
  • RC3H1 was confirmed as a direct target of miR-3613-3p, where its overexpression counteracted miR-3613-3p’s protective effects.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69d893626c1944d70ce045d0https://doi.org/10.1002/jbt.70786
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