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May 23, 2026European journal of medical researchOpen Access

Significance of miR-629-5p in the prediction of acute coronary syndrome onset, severity, and development

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Key result

Lower serum miR-629-5p distinguishes ACS from stable chest pain and predicts adverse outcomes.

  • n=218

Why the study?

Non-invasive screening of ACS is a clinical challenge, leading investigators to evaluate the significance of miR-629-5p in ACS onset and development as a novel biomarker.

Does serum miR-629-5p level predict the onset, severity, and 1-year adverse outcomes in patients with acute coronary syndrome?

Population

115 ACS patients and 103 chest pain cases

Comparison

Serum miR-629-5p in ACS patients vs chest pain cases

Authors

QWQingli WangSWShuo WangLZLiping Zhu

Discussion

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Member takes

Overview

Should not change ACS practice; leaves open prospective validation of miR-629-5p as a biomarker.

Key Points

  • Assess the role of miR-629-5p as a biomarker for predicting acute coronary syndrome (ACS) onset and outcomes.
  • Compared serum miR-629–5p levels between 115 ACS patients and 103 chest pain cases.
  • Conducted in vitro evaluation with hypoxia/reoxygenation-induced H9c2 cells.
  • Measured correlations with CK-MB, D-D, Fibrinogen, SYNTAX and Gensini scores.
  • Low serum miR-629–5p levels in ACS patients predicted risk and adverse outcomes (p<0.01).
  • miR-629–5p correlated negatively with CK-MB, D-D, and Fibrinogen levels (p<0.05).
  • Overexpression improved cell viability and reduced inflammation and oxidative stress in H/R-induced myocardial cells.

Study Design

Type

Case-Control (n=218)

Multicenter

No

Structured PICO

Does serum miR-629-5p level predict the onset, severity, and 1-year adverse outcomes in patients with acute coronary syndrome?

P
Population
115 patients with acute coronary syndrome (20 STEMI, 41 NSTEMI, 54 unstable angina) and 103 matched control patients with stable chest pain (71 typical stable angina, 7 atypical ischemic chest pain, 25 non-cardiac stable chest pain). In vitro model: hypoxia/reoxygenation (H/R)-induced H9c2 cells.
I
Intervention
Measurement of serum miR-629-5p levels as a biomarker; in vitro overexpression of miR-629-5p.
C
Comparator
Patients with stable chest pain (clinical control group); negative control or MMP16 overexpression (in vitro).
O
Outcome
Diagnostic accuracy of miR-629-5p for ACS onset and predictive value for 1-year Major Adverse Cardiac Events (MACEs: recurrent angina pectoris, ischemic stroke, severe arrhythmia, heart failure, and all-cause mortality).surrogate

Serum miR-629-5p is a promising non-invasive biomarker for diagnosing acute coronary syndrome and predicting 1-year adverse outcomes, potentially by regulating MMP16-mediated myocardial injury.

Limitations

  • Small sample size
  • Single-center study
  • Short study period
  • Single time-point evaluation of miR-629-5p (expression might change with disease development)

Cite This Study

Wang et al. (2026) conducted a case-control in Acute coronary syndrome (n=218). Serum miR-629-5p vs. Stable chest pain was evaluated on ACS onset and adverse outcomes (MACEs). Decreased serum miR-629-5p levels significantly discriminated acute coronary syndrome patients from those with stable chest pain and predicted adverse outcomes.

synapsesocial.com/papers/6a1145e548a409a3a49df748https://doi.org/10.1186/s40001-026-04567-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Upregulation of Serum miRNA-3615 Serves as a Biomarker to Predict Disease Onset and Prognosis in Acute Coronary Syndrome Patients2026
  2. 2Dysregulation of Serum miR-212-3p Serves as a Biomarker to Predict Disease Onset and Short-Term Prognosis in Acute Coronary Syndrome Patients2025 · 1 citations
  3. 3Downregulation of serum miR-30c-5p serves as a biomarker to predict disease onset and short-term prognosis in acute coronary syndrome patients2025 · 5 citations
  4. 4miR‐3613‐3p Is a New Diagnostic Indicator of Acute Coronary Syndrome (ACS) That Reduces Endothelial Damage by Targeting Ring Finger and CCCH‐Type Domains 1 (RC3H1)2026
  5. 5Diagnostic and prognostic value of miR-885-5p in acute coronary syndrome and its regulatory mechanisms in endothelial injury.2026