Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 4, 2025Journal of Cardiothoracic SurgeryOpen Access

Downregulation of serum miR-30c-5p serves as a biomarker to predict disease onset and short-term prognosis in acute coronary syndrome patients

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Timely intervention reduces ACS mortality, but convenient biomarkers for diagnosing ACS and establishing clinical significance are needed.

Does serum miR-30c-5p expression predict disease onset and short-term prognosis in patients with acute coronary syndrome?

Population

173 subjects (98 ACS subjects and 65 healthy subjects)

Comparison

ACS subjects vs healthy subjects

Design

Observational cohort study

Authors

BCBo ChangXZXiangfeng ZhangHLHuibin Li

Discussion

Loading...

Member takes

Overview

Should not yet change ACS diagnosis or short-term risk stratification; leaves open incremental value beyond troponin in larger prospective studies.

Structured PICO

Does serum miR-30c-5p expression predict disease onset and short-term prognosis in patients with acute coronary syndrome?

P
Population
173 subjects including 98 patients with acute coronary syndrome (ACS) (31 with unstable angina pectoris, 68 with acute myocardial infarction) and 65 healthy individuals, aged 18-80 years.
I
Intervention
Measurement of serum miR-30c-5p expression
C
Comparator
Healthy controls (for diagnosis) and high vs. low miR-30c-5p expression (for prognosis)
O
Outcome
Diagnostic value for ACS (measured by ROC curve) and prognostic value for Major Adverse Cardiovascular Events (MACE) at 6 months follow-upcomposite

Downregulation of serum miR-30c-5p serves as a potential diagnostic biomarker for acute coronary syndrome and an independent predictor of short-term major adverse cardiovascular events.

Limitations

  • Sample size was relatively small
  • Potential regulatory mechanism of miR-30c-5p in ACS was not fully explored

Cite This Study

Chang et al. (2025) studied this question.

synapsesocial.com/papers/6a80586cc48c717e4deeb189https://doi.org/10.1186/s13019-024-03258-w
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genes associated with inflammation and the cell cycle may serve as biomarkers for the diagnosis and prognosis of acute myocardial infarction in a Chinese population2018 · 22 citations
  2. 2Utilizing Chinese Admission Records for MACE Prediction of Acute Coronary Syndrome2016 · 31 citations
  3. 3Cardiac biomarkers of acute coronary syndrome: from history to high-sensitivity cardiac troponin2017 · 320 citations
  4. 4Heart-Type Fatty Acid Binding Protein: A Better Cardiac Biomarker than CK-MB and Myoglobin in the Early Diagnosis of Acute Myocardial Infarction2015 · 39 citations
  5. 5NORAD modulates miR-30c-5p-LDHA to protect lung endothelial cells damage2022 · 9 citations