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June 20, 2026Journal of Cardiothoracic SurgeryOpen Access

Clinical role and mechanism of miR-4443 in coronary heart disease: a prognostic marker and regulator of vascular smooth muscle cell Function

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Authors

RSRongguo SunJHJichun HaoGJGuowei Jia

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Overview

Randomized trial investigates miR-4443 as a prognostic marker in coronary heart disease, suggesting therapeutic applications.

Key Points

  • This study aims to evaluate the role of miR-4443 in vascular smooth muscle cell function and its potential as a prognostic biomarker for coronary heart disease.
  • Analyzed clinical data from 200 CHD patients retrospectively.
  • Quantified miR-4443 levels via RT-qPCR in plasma specimens and VSMCs exposed to oxidized low-density lipoprotein.
  • Used Kaplan-Meier and multivariate Cox regression analysis to assess prognostic relevance.
  • CHD patients had significantly higher serum miR-4443 levels than healthy controls.
  • High miR-4443 expression correlated with adverse cardiovascular events (HR = 2.812, 95% CI: 1.130-6.997, P = 0.026).
  • MiR-4443 promoted VSMC proliferation and migration, targeting TIMP2.

Cite This Study

Sun et al. (2026) studied this question.

synapsesocial.com/papers/6a362e1edb0793dc1a535f4ahttps://doi.org/10.1186/s13019-026-04391-4
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Also Consider

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  1. 1Clinical value and regulatory role of miR-4446-3p in coronary heart disease2026
  2. 2miR-3150b-3p Promotes Vascular Smooth Muscle Cell Injury by Targeting ARL5B2025
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  4. 4Investigation on the clinical potential of miR-193a-3p in carotid artery stenosis and its mechanism in regulating oxidized low-density lipoprotein-induced human vascular smooth muscle cells2026
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