Why the study?
MiR-146b-5p has been implicated in multiple pathologies, but its role in acute myocardial infarction remained unexplored.
Population
103 AMI patients and 95 healthy controls
Comparison
AMI patients vs healthy controls
Design
Case-control and in vitro study
Key result
Upregulated miR-146b-5p expression was observed in 103 AMI patients compared to 95 healthy controls, demonstrating diagnostic value and predicting poor prognosis.
Authors
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May aid AMI diagnosis if replicated; first human data extends miR-146b-5p observations to acute coronary syndromes.
Case-Control (n=198)
miR-146b-5p is upregulated in AMI, correlates with disease severity and poor prognosis, and promotes endothelial injury by targeting PRKAR2A, suggesting it as a potential biomarker and therapeutic target.
Wu et al. (2026) conducted a case-control in Acute myocardial infarction (n=198). miR-146b-5p expression vs. Healthy controls was evaluated on Diagnosis and prognosis of acute myocardial infarction. Upregulated miR-146b-5p expression was observed in 103 AMI patients compared to 95 healthy controls, demonstrating diagnostic value and predicting poor prognosis.