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January 13, 2020Journal of Clinical and Translational ResearchOpen Access

Circulating plasma microRNA-126, microRNA-145, and microRNA-155 and their association with atherosclerotic plaque characteristics

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Why the study?

Dysregulation of miRNA-126, -145, and -155 is linked to atherosclerotic lesion formation, but their association with unfavourable atherosclerotic plaque characteristics needed evaluation.

Comparison

Levels of circulating miRNA-126, miRNA-145, and miRNA-155

Design

Prospective study

Authors

EKEvija KnokaKTKārlis TrušinskisInterventional / Structural CardiologyMMM. Mazule

Discussion

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Implication

miRNA-plaque associations in stable CAD warrant prospective validation; leaves open biomarker utility for risk stratification.

Structured PICO

P
Population
40 patients with stable coronary artery disease (CAD) admitted for elective percutaneous coronary intervention (PCI)
O
Outcome
Proportion of fibrotic, necrotic, lipidic and calcific tissue within atherosclerotic plaques assessed by IVUS and iMAP-IVUSsurrogate

Circulating miRNA-126 and miRNA-145 are associated with increased plaque necrolipidic tissue content and may serve as potential biomarkers for plaque vulnerability.

Cite This Study

Knoka et al. (2020) studied this question.

synapsesocial.com/papers/6a905d689f954bcfeb909c7fhttps://doi.org/10.18053/jctres.05.201902.002
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Also Consider

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  4. 4Hematopoietic miR155 Deficiency Enhances Atherosclerosis and Decreases Plaque Stability in Hyperlipidemic Mice2012 · 145 citations
  5. 5Characterisation of atherosclerotic plaque by spectral similarity of radiofrequency intravascular ultrasound signals2009 · 133 citations