Key result
Circulating miR-133b was associated with lipid-rich coronary plaques in patients with stable coronary artery disease, with an estimated 18% increase in odds of lipid-rich plaques per unit increase.
Why the study?
Is there an association between circulating microRNAs and lipid-rich coronary plaques in statin-treated patients with stable coronary artery disease?
Population
47 statin-treated patients with stable coronary artery disease undergoing percutaneous coronary intervention.
Design
Cross-sectional
Authors
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Circulating miRs may identify lipid-rich plaques in stable CAD; hypothesis-generating and requires prospective validation before clinical use.
Cross-Sectional (n=47)
No
Is there an association between circulating microRNAs and lipid-rich coronary plaques in statin-treated patients with stable coronary artery disease?
Odds Ratio: 1.18
Circulating miR-133b is modestly associated with lipid-rich coronary plaques in statin-treated patients with stable CAD, suggesting potential as a biomarker for vulnerable plaques.
Sæther et al. (2023) conducted a cross-sectional in Stable coronary artery disease (n=47). Circulating microRNA-133b (miR-133b) vs. Lower levels of miR-133b was evaluated on Presence of lipid-rich coronary plaques (maxLCBI4mm ≥ 324.7) (OR 1.18). Circulating miR-133b was associated with lipid-rich coronary plaques in patients with stable coronary artery disease, with an estimated 18% increase in odds of lipid-rich plaques per unit increase.
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