What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Angina pectoris with coronary plaque (n=32). Intervention: Transcoronary concentration gradient of circulating miR-100. Primary outcome: Correlation between transcoronary concentration gradient of circulating miR-100 and percentage of lipid volume (%LV) and fibrous volume (%FV) (r=0.53 for %LV; r=-0.56 for %FV, p=<0.01).

December 16, 2014Circulation JournalOpen Access

Plasma MicroRNA-100 Is Associated With Coronary Plaque Vulnerability

Q: What are the key findings of this study?

The transcoronary concentration gradient of circulating miR-100 was positively correlated with coronary plaque lipid volume (r=0.53, P<0.01) and negatively correlated with fibrous volume (r=-0.56, P<0.01).

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Key result

The transcoronary concentration gradient of circulating miR-100 was positively correlated with coronary plaque lipid volume (r=0.53, P<0.01) and negatively correlated with fibrous volume (r=-0.56, P<0.01).

Why the study?

Does the transcoronary concentration gradient of circulating miR-100 correlate with coronary plaque vulnerability in patients with angina pectoris undergoing PCI?

Population

32 patients with angina pectoris with ≥50% stenosis of at least 1 coronary artery who underwent percutaneous…

Design

Cross-sectional, IVUS measurements were performed independently by 2…

Authors

TSTakeshi SoekiCardiac Imaging KYKoji YamaguchiTokushima University Hospital TNToshiyuki NikiTokushima Prefectural Central Hospital

Discussion

Member takes

Implication

Supports miR-100 gradient as candidate vulnerability biomarker; hypothesis-generating and should not yet change practice.

Study Design

Type

Cross-Sectional (n=32)

Blinding

Single-blind (IVUS measurements blinded to clinical characteristics)

Multicenter

Structured PICO

Does the transcoronary concentration gradient of circulating miR-100 correlate with coronary plaque vulnerability in patients with angina pectoris undergoing PCI?

Population

32 patients with angina pectoris and ≥50% coronary stenosis undergoing percutaneous coronary intervention, assessed for coronary plaque vulnerability.

Exposure

Measurement of circulating microRNAs (including miR-100) in EDTA-plasma simultaneously obtained from the aorta and the coronary sinus (CS) during cardiac catheterization to determine the transcoronary concentration gradient.

Outcome

Correlation of plasma miR-100 levels (in the aorta and the transcoronary concentration gradient) with the percentage of lipid volume (%LV) and fibrous volume (%FV) of coronary plaques as determined by integrated backscatter intravascular ultrasound (IB-IVUS).surrogate

Main Result

Effect estimate: r=0.53 for %LV; r=-0.56 for %FV

p-value: p=<0.01

The transcoronary concentration gradient of circulating miR-100 correlates significantly with lipid-rich vulnerable coronary plaques, suggesting its potential utility as a biomarker for plaque vulnerability.

Limitations

Small sample size
Measured plasma level of miRNAs in only a limited number of patients, unable to definitively exclude the predictive value of other miRNAs
Could not determine whether the increased miR-100 level in the coronary sinus was a consequence or a cause of vulnerable plaque
Measured plasma level of miRNAs in only a limited number of patients
Could not determine whether the increased miR-100 level in the CS was a consequence or a cause of vulnerable plaque

Cite This Study

Soeki et al. (2014) conducted a cross-sectional in Angina pectoris with coronary plaque (n=32). Transcoronary concentration gradient of circulating miR-100 was evaluated on Correlation between transcoronary concentration gradient of circulating miR-100 and percentage of lipid volume (%LV) and fibrous volume (%FV) (r=0.53 for %LV; r=-0.56 for %FV, p=<0.01). The transcoronary concentration gradient of circulating miR-100 was positively correlated with coronary plaque lipid volume (r=0.53, P<0.01) and negatively correlated with fibrous volume (r=-0.56, P<0.01).

synapsesocial.com/papers/6a9d8ff0894d4c85b98b18e9 https://doi.org/10.1253/circj.cj-14-0958

Topics

Coronary artery disease

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December 16, 2014Circulation JournalOpen Access

Plasma MicroRNA-100 Is Associated With Coronary Plaque Vulnerability

View Full Paper

Ask AI

Bookmark

Key result

Why the study?

Does the transcoronary concentration gradient of circulating miR-100 correlate with coronary plaque vulnerability in patients with angina pectoris undergoing PCI?

Population

32 patients with angina pectoris with ≥50% stenosis of at least 1 coronary artery who underwent percutaneous…

Design

Cross-sectional, IVUS measurements were performed independently by 2…

Authors

TSTakeshi SoekiCardiac Imaging KYKoji YamaguchiTokushima University Hospital TNToshiyuki NikiTokushima Prefectural Central Hospital

Discussion

Member takes

Implication

Supports miR-100 gradient as candidate vulnerability biomarker; hypothesis-generating and should not yet change practice.

Study Design

Type

Cross-Sectional (n=32)

Blinding

Single-blind (IVUS measurements blinded to clinical characteristics)

Multicenter

Structured PICO

Does the transcoronary concentration gradient of circulating miR-100 correlate with coronary plaque vulnerability in patients with angina pectoris undergoing PCI?

Population

32 patients with angina pectoris and ≥50% coronary stenosis undergoing percutaneous coronary intervention, assessed for coronary plaque vulnerability.

Exposure

Outcome

Main Result

Effect estimate: r=0.53 for %LV; r=-0.56 for %FV

p-value: p=<0.01

Limitations

Small sample size
Measured plasma level of miRNAs in only a limited number of patients, unable to definitively exclude the predictive value of other miRNAs
Could not determine whether the increased miR-100 level in the coronary sinus was a consequence or a cause of vulnerable plaque
Measured plasma level of miRNAs in only a limited number of patients
Could not determine whether the increased miR-100 level in the CS was a consequence or a cause of vulnerable plaque

Cite This Study

synapsesocial.com/papers/6a9d8ff0894d4c85b98b18e9 https://doi.org/10.1253/circj.cj-14-0958

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Topics

Coronary artery disease

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