Key result
Troponin-positive acute coronary syndrome was associated with significantly elevated aortic levels of miR-499 (>20-fold), miR-133a (11-fold), and miR-208a (5-fold) compared to stable CAD (all P<0.01).
Population
57 patients, including those without coronary artery disease, with stable coronary artery disease, and with…
Design
Cross-sectional
Authors
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Hypothesis-generating for cardiac miRNAs as ACS biomarkers; prospective validation required before clinical adoption.
Observational (n=57)
p-value: p=<0.01
Muscle-enriched microRNAs (miR-499 and miR-133a) are released from the heart into the coronary circulation during myocardial injury, highlighting their potential utility as cardiac biomarkers.
Rosa et al. (2011) conducted an observational in Coronary artery disease and acute coronary syndromes (n=57). Troponin-positive acute coronary syndrome vs. Stable coronary artery disease was evaluated on Circulating levels of muscle-enriched miRs in the aorta (p=<0.01). Troponin-positive acute coronary syndrome was associated with significantly elevated aortic levels of miR-499 (>20-fold), miR-133a (11-fold), and miR-208a (5-fold) compared to stable CAD (all P<0.01).
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