Key result
Troponin-positive acute coronary syndrome was associated with significantly elevated aortic levels of miR-499 (>20-fold), miR-133a (11-fold), and miR-208a (5-fold) compared to stable CAD (all P<0.01).
Observational (n=57)
p-value: p=<0.01
Muscle-enriched microRNAs (miR-499 and miR-133a) are released from the heart into the coronary circulation during myocardial injury, highlighting their potential utility as cardiac biomarkers.
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Hypothesis-generating for cardiac miRNAs as ACS biomarkers; prospective validation required before clinical adoption.
Rosa et al. (2011) conducted an observational in Coronary artery disease and acute coronary syndromes (n=57). Troponin-positive acute coronary syndrome vs. Stable coronary artery disease was evaluated on Circulating levels of muscle-enriched miRs in the aorta (p=<0.01). Troponin-positive acute coronary syndrome was associated with significantly elevated aortic levels of miR-499 (>20-fold), miR-133a (11-fold), and miR-208a (5-fold) compared to stable CAD (all P<0.01).
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