October 19, 2011Arteriosclerosis Thrombosis and Vascular Biology
Circulating MicroRNAs
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Discussion
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Implication
Review reveals distinct circulating microRNA profile alterations in cardiovascular diseases, highlighting their potential as noninvasive diagnostic and prognostic biomarkers.
Key Points
- Summarize clinical and experimental evidence on the utility of circulating microRNAs as diagnostic and prognostic biomarkers in cardiovascular disease, alongside their release mechanisms.
- Reviewed literature investigating the stability and extracellular export mechanisms of circulating microRNAs.
- Assessed clinical and experimental data profiling circulating microRNA concentrations in acute myocardial infarction, coronary artery disease, and diabetes.
- Acute myocardial infarction leads to elevated blood levels of cardiac-specific microRNAs, including miR-1, miR-133, miR-499, and miR-208.
- Coronary artery disease and diabetes are associated with decreased circulating levels of endothelial-enriched microRNAs, notably miR-126.
Cite This Study
Fichtlscherer et al. (2011) studied this question.