Key result
Circulating microRNAs emerge as promising diagnostic and prognostic biomarkers for myocardial damage in ACS.
Why the study?
Circulating microRNAs have emerged as promising diagnostic and prognostic biomarkers in ACS, but recent advances and challenges in their assessment require summarization.
Do circulating microRNAs serve as diagnostic and prognostic biomarkers in patients with acute coronary syndrome?
Do circulating microRNAs serve as diagnostic and prognostic biomarkers in patients with acute coronary syndrome?
Circulating microRNAs, particularly cardiac-enriched ones, show promise as diagnostic and prognostic biomarkers for acute coronary syndrome.
May inform ACS biomarker strategies; hypothesis-generating and should not change practice without prospective validation.
Micro-ribonucleic acids (miRs) are small, non-coding RNAs, which play an important role in atherosclerotic plaque formation, development, and stability. Plaque destabilization and rupture lead to acute coronary syndromes (ACS). Previous studies have implicated several different miRs in the pathogenesis of atherosclerosis. Several circulating miRs have emerged as promising diagnostic and prognostic biomarkers in ACS. Particularly cardiac- and muscle-enriched miRs including miR-1, miR-133a, miR-133b, miR-208a, and miR-499 have been associated with myocardial damage and thus proposed as potential biomarkers of ACS. In this review we summarize the role of circulating miRs as biomarkers for diagnosis and prognosis in patients with ACS, as well as recent advances and remaining challenges of miRs assessment.
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Stojković et al. (2024) conducted a review in Acute coronary syndrome. Circulating microRNAs was evaluated. Circulating microRNAs, particularly miR-1, miR-133a, miR-133b, miR-208a, and miR-499, have emerged as promising diagnostic and prognostic biomarkers for myocardial damage in acute coronary syndrome.
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