Key result
Positive transcoronary microRNA gradients were observed in patients with stable systolic heart failure but not in controls without structural cardiac disease (p=0.03).
Why the study?
Do transcoronary gradients of specific microRNAs differ between patients with stable systolic heart failure and controls?
Observational
Do transcoronary gradients of specific microRNAs differ between patients with stable systolic heart failure and controls?
p-value: p=0.03
The presence of positive transcoronary gradients of miR-423-5p in heart failure patients suggests a cardiac origin for these elevated circulating microRNAs.
Supports cardiac miRNA release in stable HF; hypothesis-generating for transcoronary biomarker validation.
CONTEXT: Elevated plasmatic microRNAs (miRs) are observed in heart failure (HF). However, the cardiac origin of these miRs remains unclear. OBJECTIVE: We calculated transcoronary gradients of miR-29b, miR-133a and miR-423-5p in 17 outpatients with stable systolic HF and in controls without structural cardiac disease. MATERIALS AND METHODS: MicroRNAs were measured by quantitative real-time polymerase chain reaction. RESULTS: Positive transcoronary miR gradients were observed in patients with HF but not in controls (p = 0.03). B-type natriuretic peptide (BNP) moderately correlated with the transcoronary gradients of miR-133a and miR-423-5p. DISCUSSION AND CONCLUSIONS: The difference in transcoronary gradients between HF outpatients and controls suggests that miR-423-5p has a cardiac origin. The positive correlation between miR-423-5p and BNP transcoronary gradients supports this hypothesis.
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Goldraich et al. (2014) conducted an observational in Heart failure. Stable systolic heart failure vs. Controls without structural cardiac disease was evaluated on Transcoronary microRNA gradients (p=0.03). Positive transcoronary microRNA gradients were observed in patients with stable systolic heart failure but not in controls without structural cardiac disease (p=0.03).
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