Key result
Systolic heart failure patients (n=39) had higher peripheral venous levels of miR-125b-5p and miR-133-3p compared to controls (n=21), with differing expression levels in the coronary sinus.
Why the study?
To assess coronary sinus miRNA levels during CRT device implantation in systolic HF patients and compare them to peripheral systemic venous expression.
Does coronary sinus miRNA expression differ from peripheral systemic venous miRNA expression in patients with systolic heart failure?
Observational (n=60)
Does coronary sinus miRNA expression differ from peripheral systemic venous miRNA expression in patients with systolic heart failure?
Local sampling of coronary sinus miRNAs reveals transvenous gradients that differ from peripheral circulation, highlighting the importance of local myocardial tissue changes in systolic heart failure.
Coronary sinus sampling may capture myocardial-specific miRNA changes in systolic HF; leaves open clinical utility versus peripheral measures.
AIMS: The aims of the study are to assess the levels of coronary sinus (CS) miRNAs of systolic heart failure (HF) patients in samples obtained during cardiac resynchronization therapy (CRT) device implantation and compare them to the peripheral systemic venous miRNA expression. METHODS AND RESULTS: The cardiac specific miRNA levels were assessed in 60 patients, 39 HF patients with reduced ejection fraction and 21 control patients. The levels of four cardiac specified miRNAs (miR-21-5p, miR-92b-3p, miR-125b-5p, and miR-133a-3p) were compared between the peripheral samples of HF and controls and between peripheral venous in CS in the HF groups. Compared with controls, HF patients had higher peripheral serum venous levels of miR-125b-5p and miR-133-3p. In the HF group, the levels of expression were higher for miR-125b-5p and lower for miR-92, and miR-21-5p in the CS, compared with the peripheral venous circulation. CONCLUSIONS: The differences in miRNA expressions in CS compared with those in the periphery suggest that changes that may occur at the levels of the myocardial tissue in HF may be more relevant to our understanding of the biological linkage between miRNA expression and HF, than the traditional analysis of systemic serum miRNA expression.
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Ben‐Zvi et al. (2020) conducted an observational in Systolic heart failure (n=60). Systolic heart failure vs. Controls was evaluated on Levels of coronary sinus and peripheral systemic venous miRNAs (miR-21-5p, miR-92b-3p, miR-125b-5p, and miR-133a-3p). Systolic heart failure patients (n=39) had higher peripheral venous levels of miR-125b-5p and miR-133-3p compared to controls (n=21), with differing expression levels in the coronary sinus.
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