What question did this study set out to answer?

To identify and validate microRNA expression patterns in peripheral blood mononuclear cells (PBMCs) from patients with chronic heart failure resulting from ischemic and nonischemic dilated cardiomyopathy.

May 19, 2010Physiological GenomicsOpen Access

MicroRNA signatures in peripheral blood mononuclear cells of chronic heart failure patients

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To identify and validate microRNA expression patterns in peripheral blood mononuclear cells (PBMCs) from patients with chronic heart failure resulting from ischemic and nonischemic dilated cardiomyopathy.
Screened 257 microRNAs via quantitative real-time PCR in a discovery cohort of 7 nonischemic dilated cardiomyopathy (NIDCM) patients, 8 ischemic cardiomyopathy (ICM) patients, and 9 healthy control subjects.
Validated candidate microRNA markers in an independent cohort consisting of 34 chronic heart failure patients (NIDCM = 19, ICM = 15) and 19 healthy control subjects.
Conducted bioinformatic analyses on predicted target genes to evaluate the downstream transcriptional impact of the identified microRNA signatures.
Three microRNAs (miR-107, miR-139, and miR-142-5p) were significantly downmodulated in both NIDCM and ICM patient groups compared with control subjects.
Etiology-specific alterations emerged across patient cohorts: miR-142-3p and miR-29b increased selectively in NIDCM, whereas miR-125b and miR-497 decreased exclusively in ICM.
Bioinformatic targeting revealed that deregulated microRNAs in both heart failure subgroups share predicted gene targets, suggesting synergistic regulatory effects on the PBMC transcriptome.

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Implication

Observational profiling reveals distinct microRNA signatures in peripheral blood mononuclear cells of chronic heart failure patients, suggesting diagnostic and prognostic utility.

Cite This Study

Voellenkle et al. (2010) studied this question.

synapsesocial.com/papers/69da2a9d0f778bd2e468477f https://doi.org/10.1152/physiolgenomics.00211.2009

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Implication

Observational profiling reveals distinct microRNA signatures in peripheral blood mononuclear cells of chronic heart failure patients, suggesting diagnostic and prognostic utility.

MicroRNA signatures in peripheral blood mononuclear cells of chronic heart failure patients

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Discussion

Implication

Cite This Study

MicroRNA signatures in peripheral blood mononuclear cells of chronic heart failure patients

Key Points

Discussion

Implication

Cite This Study

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