Key result
Congestive heart failure was associated with a distinct transcardiac gradient, with the failing heart releasing specific microRNAs like let-7b-5p and absorbing others like miR-16-5p.
Observational (n=17)
The failing heart exhibits a distinct transcardiac gradient of specific microRNAs, supporting their potential use as biomarkers and suggesting a role in heart failure pathophysiology.
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Transcardiac miRNA gradients in HF may inform biomarker panels; hypothesis-generating for pathophysiology, needs prospective validation.
Marques et al. (2016) conducted an observational in Congestive heart failure (n=17). Congestive heart failure vs. Healthy volunteers was evaluated on Transcardiac gradient of 84 cardio-microRNAs. Congestive heart failure was associated with a distinct transcardiac gradient, with the failing heart releasing specific microRNAs like let-7b-5p and absorbing others like miR-16-5p.
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