Key result
Reactivation of a fetal microRNA program in failing human hearts substantially contributes to alterations of gene expression and induces cellular hypertrophy.
Reactivation of a fetal microRNA program contributes to the transcriptional changes and cellular hypertrophy observed in the failing human heart.
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May inform microRNA-targeted HF therapies; leaves open clinical translation from human tissue findings.
Thum et al. (2007) studied Chronic heart failure. Reactivation of a fetal microRNA program in failing human hearts substantially contributes to alterations of gene expression and induces cellular hypertrophy.
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