Key result
Cardiomyocyte-specific deletion of dgcr8, a gene required for microRNA biogenesis, leads to a fully penetrant phenotype of left ventricular malfunction, dilated cardiomyopathy, and premature lethality.
Population
Adult heart model (cardiomyocytes)
Design
Preclinical
Authors
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MicroRNA biogenesis is required for adult cardiomyocyte homeostasis; animal data leave open whether miRNA modulation can treat human dilated cardiomyopathy.
MicroRNAs are essential for maintaining cardiac function in mature cardiomyocytes, and their global loss leads to rapid progression of dilated cardiomyopathy and heart failure.
Rao et al. (2009) studied Heart failure and dilated cardiomyopathy. Cardiomyocyte-specific deletion of dgcr8 was evaluated on Cardiac phenotype (left ventricular malfunction, dilated cardiomyopathy, premature lethality). Cardiomyocyte-specific deletion of dgcr8, a gene required for microRNA biogenesis, leads to a fully penetrant phenotype of left ventricular malfunction, dilated cardiomyopathy, and premature lethality.
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