Key result
Circulating miR-3135b, miR-3908, and miR-5571-5p accurately discriminated heart failure patients from controls (AUCs of 1.00, 0.86, and 0.94, respectively; P<0.001).
Why the study?
Do circulating miRNAs (miR-3135b, miR-3908, miR-5571-5p) accurately diagnose heart failure and differentiate HFrEF from HFpEF compared to controls?
Population
69 participants total: discovery cohort of 13 heart failure patients and 3 controls, and an independent…
Comparison
Measurement of circulating plasma microRNAs vs Healthy controls
Design
Case-control
Authors
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These miRNAs are hypothesis-generating for HF diagnosis and subtype differentiation; leaves open clinical utility pending prospective validation.
Case-Control (n=69)
Do circulating miRNAs (miR-3135b, miR-3908, miR-5571-5p) accurately diagnose heart failure and differentiate HFrEF from HFpEF compared to controls?
Effect estimate: AUC 1.00, 0.86, and 0.94
p-value: p=<0.001
Circulating miR-3135b, miR-3908, and miR-5571-5p demonstrate high diagnostic accuracy for heart failure and may help differentiate HFrEF from HFpEF.
Chen et al. (2017) conducted a case-control in Heart failure (n=69). Circulating miRNAs (miR-3135b, miR-3908, miR-5571-5p) vs. Controls was evaluated on Discrimination of heart failure from controls (AUC 1.00, 0.86, and 0.94, p=<0.001). Circulating miR-3135b, miR-3908, and miR-5571-5p accurately discriminated heart failure patients from controls (AUCs of 1.00, 0.86, and 0.94, respectively; P<0.001).
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