What does this research mean for the field?

Specific circulating microRNAs can serve as biomarkers to distinguish heart failure from non-heart failure controls and differentiate between reduced and preserved ejection fraction phenotypes, demonstrating stronger discriminative power than NT-proBNP alone. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 23, 2015European Journal of Heart FailureOpen Access

Circulating microRNAs in Heart Failure with Reduced and Preserved Left Ventricular Ejection Fraction

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Why the study?

Can circulating microRNAs distinguish between heart failure phenotypes (HFrEF vs HFpEF) and non-HF controls?

Structured PICO

Can circulating microRNAs distinguish between heart failure phenotypes (HFrEF vs HFpEF) and non-HF controls?

Population

176 subjects including heart failure patients (HFrEF and HFpEF) and non-HF controls, split into a profiling cohort (28 controls, 39 HFrEF, 19 HFpEF) and an independent validation cohort (30 controls, 30 HFrEF, 30 HFpEF)

Intervention

Circulating microRNA profiling from whole blood and plasma

Comparator

Non-HF controls and comparison between HF phenotypes (HFrEF vs HFpEF)

Outcome

Discriminative power of microRNAs to distinguish HF from controls and HFrEF from HFpEFsurrogate

Specific circulating microRNAs can serve as potential biomarkers to distinguish heart failure from controls and differentiate between HFrEF and HFpEF, potentially outperforming NT-proBNP.

Discussion

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Implication

MicroRNA panels may distinguish HFrEF from HFpEF; leaves open prospective validation and clinical utility beyond NT-proBNP.

Cite This Study

Wong et al. (2015) studied this question.

synapsesocial.com/papers/6a1d244e34b1fc2f2476e7ab https://doi.org/10.1002/ejhf.223

Topics

HFrEF treatment Heart failure

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Circulating microRNAs in Heart Failure with Reduced and Preserved Left Ventricular Ejection Fraction

Structured PICO

Discussion

Implication

Cite This Study

Topics

Circulating microRNAs in Heart Failure with Reduced and Preserved Left Ventricular Ejection Fraction

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider