March 4, 2015European Journal of Heart FailureOpen Access

MicroRNA Signatures Differentiate Preserved from Reduced Ejection Fraction Heart Failure

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Why the study?

Does a circulating microRNA panel combined with BNP improve the differentiation of HFpEF from HFrEF compared to BNP alone in patients with heart failure?

Population

Patients with no heart failure, HFrEF, and HFpEF. Validation cohort n=225.

Comparison

Circulating microRNA panel combined with BNP vs BNP alone

Design

Cohort

Authors

CWChris WatsonHeart Failure & Transplant SGShashi Kumar GuptaCentral Drug Research Institute EOEoin O’ConnellUniversity of Limerick

Discussion

Member takes

Implication

May aid HFpEF vs HFrEF differentiation beyond BNP; hypothesis-generating in observational data, requiring prospective validation.

Structured PICO

Does a circulating microRNA panel combined with BNP improve the differentiation of HFpEF from HFrEF compared to BNP alone in patients with heart failure?

Population

Patients with no heart failure, HFrEF, and HFpEF. Validation cohort n=225.

Intervention

Circulating microRNA (miRNA) panel (miR-30c, -146a, -221, -328, and -375) combined with BNP

Comparator

BNP alone

Outcome

Differentiation of HFpEF from HFrEFsurrogate

A panel of circulating miRNAs combined with BNP improves the diagnostic differentiation between HFpEF and HFrEF compared to BNP alone.

Cite This Study

Watson et al. (2015) studied this question.

synapsesocial.com/papers/6a7de56a02c864aefccb4f1e https://doi.org/10.1002/ejhf.244

Topics

HFrEF treatment Heart failure

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MicroRNA Signatures Differentiate Preserved from Reduced Ejection Fraction Heart Failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

MicroRNA Signatures Differentiate Preserved from Reduced Ejection Fraction Heart Failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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