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May 4, 2023IJC Heart & VasculatureOpen Access

Circulating Lp(a) (78.1% presence in resampled datasets) and free cholesterol in the smallest HDL subfractions (74.3%) showed modest potential as predictors for coronary plaque lipid content.

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Why the study?

Are circulating lipoprotein subfractions associated with lipid content in coronary atheromatous plaques in statin-treated patients with stable CAD?

Population

56 statin-treated patients with stable coronary artery disease undergoing percutaneous coronary intervention

Design

Cross-sectional

Key result

Circulating Lp(a) (78.1% presence in resampled datasets) and free cholesterol in the smallest HDL subfractions (74.3%) showed modest potential as predictors for coronary plaque lipid content.

Authors

JSJulie Caroline SætherEVElisabeth Kleivhaug VesterbekkmoBGBruna Gigante

Discussion

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Overview

Lipoprotein subfractions may reflect coronary plaque lipid content in stable CAD; hypothesis-generating for refined risk assessment pending prospective validation.

Study Design

Type

Observational (n=56)

Structured PICO

Are circulating lipoprotein subfractions associated with lipid content in coronary atheromatous plaques in statin-treated patients with stable CAD?

P
Population
56 statin-treated patients with stable coronary artery disease undergoing percutaneous coronary intervention.
E
Exposure
Measurement of circulating lipoprotein subfractions and Lipoprotein a (Lp(a))
O
Outcome
Lipid content in coronary atheromatous plaques, defined as the maximum lipid core burden index within any 4 mm length across the entire lesion (maxLCBI4mm) assessed by near-infrared spectroscopy (NIRS)surrogate

Circulating lipoprotein subfractions provide modest information regarding coronary plaque lipid content, but do not add predictive value beyond established cardiovascular risk factors.

Limitations

  • Small sample size requiring further and larger studies
  • small sample size

Cite This Study

Sæther et al. (2023) conducted an observational in Stable coronary artery disease (n=56). Circulating lipoprotein subfractions was evaluated on Maximum lipid core burden index within any 4 mm length (maxLCBI4mm). Circulating Lp(a) (78.1% presence in resampled datasets) and free cholesterol in the smallest HDL subfractions (74.3%) showed modest potential as predictors for coronary plaque lipid content.

synapsesocial.com/papers/6ab5dac0839ad79bfd448ca5https://doi.org/10.1016/j.ijcha.2023.101215
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Circulating Lipoprotein(a) and Non-culprit Lipid-rich Plaques in Acute Coronary Syndrome and Stable Coronary Artery Disease: Findings from Near-infrared Spectroscopy Imaging Analysis2025
  2. 2High density lipoprotein subfractions and extent of coronary atherosclerotic lesions: From the cordioprev study2022 · 4 citations
  3. 3Circulating protein biomarkers and their association with vulnerable plaque characteristics – a PROSPECT II substudy2025 · 2 citations
  4. 4Associations between circulating microRNAs and lipid-rich coronary plaques measured with near-infrared spectroscopy2023 · 4 citations
  5. 5Genetic associations with lipoprotein subfractions provide information on their biological nature2011 · 33 citations