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March 11, 2014European Heart Journal - Cardiovascular ImagingOpen Access

Plasma lipidomic analysis predicts non-calcified coronary artery plaque in asymptomatic patients at intermediate risk of coronary artery disease

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Key result

Plasma lipidomic analysis identified 18 lipid species significantly associated with non-calcified coronary plaque burden in asymptomatic patients at intermediate CAD risk.

Why the study?

Does plasma lipidomic analysis predict non-calcified coronary artery plaque burden in asymptomatic patients at intermediate risk of CAD?

Population

100 asymptomatic patients at intermediate CAD risk according to the Framingham risk score

Design

Cross-sectional

Authors

AEA. EllimsGWGary K. W. WongJWJacquelyn M. Weir

Discussion

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Overview

May support risk re-stratification in intermediate CAD; hypothesis-generating and requires prospective validation before clinical use.

Study Design

Type

Observational (n=100)

Structured PICO

Does plasma lipidomic analysis predict non-calcified coronary artery plaque burden in asymptomatic patients at intermediate risk of CAD?

P
Population
100 asymptomatic patients at intermediate CAD risk according to the Framingham risk score
I
Intervention
Plasma lipid profiling (lipidomic analysis)
O
Outcome
Burden of non-calcified coronary artery plaque assessed by CCTA (Segment stenosis scores)surrogate

Plasma lipidomic analysis can predict the burden of non-calcified coronary plaque in asymptomatic subjects at intermediate risk of CAD, potentially aiding in risk re-stratification.

Cite This Study

Ellims et al. (2014) conducted an observational in Asymptomatic intermediate risk of coronary artery disease (n=100). Plasma lipidomic analysis was evaluated on Burden of total, calcified, and non-calcified coronary artery plaque. Plasma lipidomic analysis identified 18 lipid species significantly associated with non-calcified coronary plaque burden in asymptomatic patients at intermediate CAD risk.

synapsesocial.com/papers/6a110e3ca334b8d43a169e66https://doi.org/10.1093/ehjci/jeu033
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