Why the study?
In PROSPECT II, NIRS-derived LCBI and IVUS-derived PB identified plaques linked to adverse cardiovascular events, but circulating biomarkers associated with these vulnerable plaque characteristics remained to be identified.
Are specific circulating protein biomarkers associated with vulnerable plaque characteristics (LCBI and PB) in patients with recent myocardial infarction?
Population
898 patients with recent myocardial infarction undergoing PCI
Comparison
Plasma levels of 179 cardiovascular disease-associated proteins evaluated against LCBI and PB
Design
Observational PROSPECT II substudy
Key result
Circulating proteins IL-18R1 and CSF-1 were strongly associated with coronary plaque burden, while ANGPTL3 was associated with lipid-rich plaques (LCBI) but not plaque burden.
Authors
Loading...
These associations are hypothesis-generating; prospective validation needed before any clinical consideration post-MI.
Observational (n=898)
Are specific circulating protein biomarkers associated with vulnerable plaque characteristics (LCBI and PB) in patients with recent myocardial infarction?
Specific circulating protein biomarkers, including ANGPTL3, IL-18R1, and CSF-1, are associated with vulnerable plaque characteristics such as lipid core burden and plaque burden in patients with recent myocardial infarction.
Sharma et al. (2025) conducted an observational in Recent myocardial infarction (n=898). Circulating protein biomarkers was evaluated on Association with NIRS-derived lipid core burden index (LCBI) or IVUS-derived plaque burden (PB). Circulating proteins IL-18R1 and CSF-1 were strongly associated with coronary plaque burden, while ANGPTL3 was associated with lipid-rich plaques (LCBI) but not plaque burden.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: