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September 14, 2018Current Atherosclerosis ReportsOpen Access

After adjustment for clinical characteristics and Bonferroni correction, IL-8 was significantly associated with all-cause mortality or ACS (HR 1.75; 95% CI 1.24-2.48 per ln (pg/ml), p = 0.0015), but no biomarker was significantly associated with LCBI.

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Population

581 patients undergoing diagnostic coronary angiography or percutaneous coronary intervention for stable…

Design

Cohort, Endpoints were adjudicated by a clinical events committee that was…

Follow-up

median 4.7 years

Authors

SASharda S. AnroedhKAK. Martijn AkkerhuisRORohit M. Oemrawsingh

Discussion

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Overview

IL-8 may aid post-angiography risk stratification; hypothesis-generating for inflammatory biomarkers without supporting LCBI correlations.

Structured PICO

P
Population
581 patients undergoing diagnostic coronary angiography or percutaneous coronary intervention for stable angina pectoris (SAP) or acute coronary syndrome (ACS). NIRS of a non-culprit vessel was performed in a subset of 203 patients (mean age 63.4, 72.9% male).
O
Outcome
Major adverse cardiac events (MACE), defined as the composite of all-cause mortality, nonfatal ACS, or unplanned coronary revascularization at median 4.7 years follow-upcomposite

In patients undergoing coronary angiography, circulating IL-8 levels independently predict long-term adverse cardiovascular events, though the tested multiplex biomarker panel does not correlate with NIRS-derived lipid core burden index.

Cite This Study

Anroedh et al. (2018) studied this question.

synapsesocial.com/papers/6a85cd9fcf8e1b2ff031a9bahttps://doi.org/10.1007/s11883-018-0752-8
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