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June 19, 2023Angiology

Multivariable logistic regression indicated inflammatory biomarkers were significantly associated with CI-AKI, including dNLR ≥2.08 (OR = 1.686, P = .007) and SIRI ≥1.13 (OR = 1.601, P = .017).

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Why the study?

The study aimed to evaluate the predictive role of inflammatory biomarkers in the development of contrast-induced acute kidney injury in acute coronary syndrome patients undergoing percutaneous coronary intervention.

Do preoperative hematological inflammatory biomarkers predict the risk of contrast-induced acute kidney injury in ACS patients undergoing PCI?

Population

950 ACS patients undergoing PCI

Comparison

Patients with CI-AKI vs without CI-AKI

Design

Cross-sectional study

Authors

ZYZhanneng YangYQYong QiaoDWDong Wang

Discussion

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Overview

Inflammatory biomarkers were associated with CI-AKI; hypothesis-generating for added value to Mehran score in prospective ACS-PCI cohorts.

Structured PICO

Do preoperative hematological inflammatory biomarkers predict the risk of contrast-induced acute kidney injury in ACS patients undergoing PCI?

P
Population
950 patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI)
I
Intervention
High levels of preoperative hematological inflammatory biomarkers (including NLR ≥2.96, dNLR ≥2.08, NLPR ≥.012, SII ≥558.04, and SIRI ≥1.13)
C
Comparator
Low levels of preoperative hematological inflammatory biomarkers
O
Outcome
Development of contrast-induced acute kidney injury (CI-AKI)safety

Preoperative hematological inflammatory markers, such as NLR and SIRI, can independently predict the risk of contrast-induced acute kidney injury and improve the predictive value of the Mehran score in ACS patients undergoing PCI.

Cite This Study

Yang et al. (2023) studied this question.

synapsesocial.com/papers/69d667a1bcbb69330b88b4d2https://doi.org/10.1177/00033197231185445
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Neutrophil Percentage-to-Albumin Ratio Predicts Contrast-Induced Acute Kidney Injury in Acute Coronary Syndrome Patients Undergoing Percutaneous Coronary Intervention2025 · 3 citations
  2. 2Neutrophil Percentage-to-Albumin Ratio Predicts Contrast-Induced Acute Kidney Injury in Acute Coronary Syndrome Patients Undergoing Percutaneous Coronary Intervention2025
  3. 3Inflammatory Biomarkers Predicting Contrast-Induced Acute Kidney Injury in Elderly Patients with ST-Segment Elevation Myocardial Infarction2025 · 4 citations
  4. 4Contrast-induced acute kidney injury and adverse clinical outcomes risk in acute coronary syndrome patients undergoing percutaneous coronary intervention: a meta-analysis2018 · 71 citations
  5. 5Inflammatory Markers and Contrast‐Induced Nephropathy Risk: A Meta‐Analysis of NLR and PLR in ACS Patients Undergoing Percutaneous Coronary Intervention2025 · 4 citations