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May 8, 2025DiagnosticsOpen Access

SII and SIRI were independent predictors of CI-AKI, with AUCs of 0.903 and 0.867, respectively (p < 0.001).

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Why the study?

The relation of the systemic immune-inflammation index and systemic inflammation response index with contrast-induced acute kidney injury in elderly patients with STEMI undergoing pPCI had not been established.

Do the systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) predict contrast-induced acute kidney injury in elderly patients with STEMI undergoing primary PCI?

Population

263 patients aged over 70 with STEMI undergoing pPCI

Comparison

Patients with CI-AKI development vs without CI-AKI development

Design

Retrospective observational study

Authors

SYSüleyman Sezai YıldızGÇGökhan ÇetinkalEKErkan Kalendar

Discussion

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Member takes

Overview

May inform CI-AKI risk stratification in elderly STEMI; hypothesis-generating and requires prospective validation.

Structured PICO

Do the systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) predict contrast-induced acute kidney injury in elderly patients with STEMI undergoing primary PCI?

P
Population
263 elderly patients (aged >70 years) with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI), mean age 77.67, 56% women.
I
Intervention
Measurement of systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI)
O
Outcome
Contrast-induced acute kidney injury (CI-AKI)safety

The systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) are strong independent predictors of contrast-induced acute kidney injury in elderly patients undergoing primary PCI for STEMI.

Cite This Study

Yıldız et al. (2025) studied this question.

synapsesocial.com/papers/6a8a46d94c30e1095aeca5b9https://doi.org/10.3390/diagnostics15101191
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Systemic Immune-Inflammation Index and Systemic Inflammatory Response Index as Predictors of Mortality in ST-Elevation Myocardial Infarction2024 · 64 citations
  2. 2Predictive value of immune inflammation index and systemic inflammation response index for contrast-induced acute kidney injury in endovascular treatment for acute ischemic stroke2025
  3. 3Association Between Inflammatory Biomarkers and Contrast-induced Acute Kidney Injury in ACS Patients Undergoing Percutaneous Coronary Intervention: A Cross-sectional Study2023 · 30 citations
  4. 4Nonlinear association between systemic inflammation response index and mortality in adult cardiac surgery–associated acute kidney injury: A retrospective Cohort study based on the MIMIC-IV database2026
  5. 5Systemic immune-inflammation index predicts in-hospital and long-term outcomes in patients with ST-segment elevation myocardial infarction2021 · 2 citations