Key result
Elevated NLR linked to ~27% greater TLR risk after PCI per SD.
Why the study?
The association between inflammatory activation and patient outcomes after coronary angiography remained widely unclear.
Do routinely available inflammation biomarkers (CRP, leukocytes, NLR) predict mortality and target lesion revascularization in patients undergoing coronary angiography?
Population
12 642 patients undergoing coronary angiography between 2010 and 2021
Comparison
Routinely used inflammation biomarkers including CRP, leukocytes, and NLR
Design
Observational study
Authors
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May support post-PCI TLR risk stratification with NLR; leaves open prospective validation before clinical use.
Observational (n=12,642)
Do routinely available inflammation biomarkers (CRP, leukocytes, NLR) predict mortality and target lesion revascularization in patients undergoing coronary angiography?
Hazard Ratio: 1.27 (95% CI 1.12–1.43)
p-value: p=<0.001
In patients undergoing coronary angiography, the neutrophil-to-lymphocyte ratio (NLR) is a robust predictor of target lesion revascularization after PCI, whereas CRP is associated with mortality but not interventional outcomes.
Steinacher et al. (2023) conducted an observational in Coronary artery disease undergoing coronary angiography (n=12,642). Inflammation biomarkers (CRP, leukocytes, NLR) was evaluated on Target lesion revascularization (TLR) (HR 1.27, 95% CI 1.12-1.43, p=<0.001). Elevated neutrophil-to-lymphocyte ratio (NLR) was significantly associated with target lesion revascularization after PCI (HR per 1 SD 1.27; 95% CI 1.12-1.43; P<0.001).
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