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February 28, 2022Physiological Genomics

Associations between circulating microRNAs and coronary plaque characteristics: potential impact from physical exercise

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Why the study?

MicroRNAs are involved in atherosclerosis development and proposed as CAD biomarkers, but their associations with RF-IVUS plaque components before and after exercise intervention remained unclear.

Are circulating microRNAs associated with coronary plaque characteristics and modified by physical exercise in patients with CAD post-PCI?

Population

Thirty-one patients with CAD treated with PCI previously included in a randomized trial

Comparison

Aerobic interval training (AIT) vs moderate continuous training (MCT)

Design

Exploratory study

Authors

MTMaria Dalen TaraldsenRWRune WisethVVVibeke Videm

Discussion

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Member takes

Overview

miR-plaque associations in small CAD cohorts should not change practice; leaves open their value as exercise-responsive biomarkers.

Structured PICO

Are circulating microRNAs associated with coronary plaque characteristics and modified by physical exercise in patients with CAD post-PCI?

P
Population
31 patients with coronary artery disease (CAD) treated with percutaneous coronary intervention (PCI) previously included in a randomized trial
I
Intervention
Aerobic interval training (AIT) or moderate continuous training (MCT) as post-PCI intervention
O
Outcome
Associations between circulating microRNAs and coronary plaque components assessed by radiofrequency intravascular ultrasound (RF-IVUS) before and after aerobic exercise interventionsurrogate

Specific circulating microRNAs are associated with coronary necrotic core volume and their changes correlate with exercise-induced regression of coronary plaque burden, highlighting their potential as biomarkers for CAD.

Limitations

  • exploratory study

Cite This Study

Taraldsen et al. (2022) studied this question.

synapsesocial.com/papers/6a702d2ce71d69abee086da2https://doi.org/10.1152/physiolgenomics.00071.2021
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Systemic microRNA profiles associated with coronary plaque stability and clinical phenotypes in patients with coronary artery disease2026
  2. 2Circulating plasma microRNA-126, microRNA-145, and microRNA-155 and their association with atherosclerotic plaque characteristics2020 · 8 citations
  3. 3Exercise-induced changes in miRNA expression in coronary artery disease2021 · 16 citations
  4. 4Circulating MicroRNA profile in coronary artery disease2025
  5. 5Circulating microRNA signatures are associated with epicardial coronary dysfunction in patients underwent invasive physiological evaluation: The ANFIBIO Study2025