Key result
Increased serum expression of miR-145-5p and miR-let7c was significantly associated with the presence of carotid plaques in hypertensive patients (Beta 0.050, p=0.016 and Beta 0.056, p=0.003).
Why the study?
Hypertension strongly predisposes to atherosclerosis, but the relationship between adverse vascular remodeling miRNAs and subclinical markers like carotid plaques and cIMT in hypertensive patients required evaluation.
Does serum expression of specific miRNAs correlate with carotid plaques and cIMT in hypertensive patients?
Cross-Sectional (n=177)
Does serum expression of specific miRNAs correlate with carotid plaques and cIMT in hypertensive patients?
Effect estimate: Beta 0.050 (miR-145-5p) and 0.056 (miR-let7c)
p-value: p=0.016 and 0.003
Hypertensive patients with carotid plaques have increased serum expression of miR-145-5p and miR-let7c, suggesting their potential as biomarkers for subclinical atherosclerosis.
May flag higher-risk hypertensives; leaves open whether miRNAs predict events or warrant targeted intervention.
Aim: Hypertension is a strong risk factor for atherosclerosis. Increased carotid intima-media thickness (cIMT) and carotid plaques are considered subclinical markers of atherosclerosis. This study aimed at evaluating the serum expression of miRNAs previously related to adverse vascular remodeling and correlating them with carotid plaques and cIMT in hypertensive patients. Methods: We cross-sectionally evaluated the clinical and carotid characteristics as well as serum expression of miR-145-5p, miR-let7c, miR-92a, miR-30a and miR-451 in 177 hypertensive patients. Carotid plaques and cIMT were evaluated by ultrasound, and the expression of selected miRNAs was evaluated by a quantitative polymerase chain reaction. Results: Among all participants (age = 60.6 ± 10.7 years, 43% males), there were 59% with carotid plaques. We observed an increased expression of miR-145-5p (Fold Change = 2.0, p = 0.035) and miR-let7c (Fold Change = 3.8, p = 0.045) in participants with atherosclerotic plaque when compared to those without plaque. In the logistic regression analysis adjusted for relevant covariates, these miRNAs showed a stronger association with carotid plaques (miR-145-5p: Beta ± SE = 0.050 ± 0.020, p = 0.016 and miR-let7c: Beta ± SE = 0.056 ± 0.019, p = 0.003). Conclusions: Hypertensive patients with carotid plaques have an increased expression of miR-145-5p and miR-let7c, suggesting a potential role of these miRNAs as a biomarker for subclinical atherosclerosis in hypertensive individuals.
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Minin et al. (2021) conducted a cross-sectional in Hypertension (n=177). Serum expression of miR-145-5p and miR-let7c vs. Lower expression was evaluated on Carotid plaques (Beta 0.050 (miR-145-5p) and 0.056 (miR-let7c), p=0.016 and 0.003). Increased serum expression of miR-145-5p and miR-let7c was significantly associated with the presence of carotid plaques in hypertensive patients (Beta 0.050, p=0.016 and Beta 0.056, p=0.003).
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