November 30, 2025Current Opinion in VirologyOpen Access

A storm is born: immune activation and pathogenesis in arthritogenic alphavirus infections

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Joint pain is linked to immune activation in chikungunya virus infections, with involvement of inflammatory cytokines.
Rapid innate immune responses involve interferons and various immune cells, including macrophages and dendritic cells.
Excessive immune activation can result in a cytokine storm and chronic synovitis, driving persistent joint pain.
Understanding immune evasion is critical, emphasizing that antiviral treatments are currently lacking.

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Implication

This review highlights how chikungunya and arthritogenic alphaviruses trigger joint pain and immune evasion, suggesting potential antiviral treatments are urgently needed.

Cite This Study

Freppel et al. (2025) studied this question.

synapsesocial.com/papers/692b94261d383f2b2a378401 https://doi.org/10.1016/j.coviro.2025.101498

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Implication

This review highlights how chikungunya and arthritogenic alphaviruses trigger joint pain and immune evasion, suggesting potential antiviral treatments are urgently needed.

A storm is born: immune activation and pathogenesis in arthritogenic alphavirus infections

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Discussion

Implication

Cite This Study

A storm is born: immune activation and pathogenesis in arthritogenic alphavirus infections

Key Points

Discussion

Implication

Cite This Study

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