November 30, 2025Advanced Synthesis & Catalysis

Harnessing the Excited‐State Reactivity of o ‐Nitrobenzyl Alcohols for the Rapid Synthesis of N ‐Substituted 2 H ‐Indazoles

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YJYifan Jiang HHHaichao Huang DSDechen Sun

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Overview

The novel method demonstrates environmentally benign synthesis of 3-arylamino-2-aryl-2H-indazoles, suggesting potential as a probe for hypochlorite detection.

Key Points

The synthesized 3-arylamino-2-aryl-2H-indazoles exhibit a selective fluorescence quenching response toward hypochlorite, indicating their potential as probes.
This novel synthesis avoids harsh reaction conditions, using environmentally benign materials and visible light irradiation.
Employing o-nitrobenzyl alcohols and a Lewis acid iron salt as a catalyst leads to efficient product formation without precious metal catalysts.
The method supports the construction of complex 2H-indazoles embedded within medium-sized rings, potentially benefiting bioactive compounds.

Cite This Study

Jiang et al. (2025) studied this question.

synapsesocial.com/papers/692b94341d383f2b2a3785ff https://doi.org/10.1002/adsc.70247

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November 30, 2025Advanced Synthesis & Catalysis

Harnessing the Excited‐State Reactivity of o ‐Nitrobenzyl Alcohols for the Rapid Synthesis of N ‐Substituted 2 H ‐Indazoles

View Full Paper

Ask AI

Bookmark

Authors

YJYifan Jiang HHHaichao Huang DSDechen Sun

Discussion

Member takes

Overview

The novel method demonstrates environmentally benign synthesis of 3-arylamino-2-aryl-2H-indazoles, suggesting potential as a probe for hypochlorite detection.

Key Points

The synthesized 3-arylamino-2-aryl-2H-indazoles exhibit a selective fluorescence quenching response toward hypochlorite, indicating their potential as probes.
This novel synthesis avoids harsh reaction conditions, using environmentally benign materials and visible light irradiation.
Employing o-nitrobenzyl alcohols and a Lewis acid iron salt as a catalyst leads to efficient product formation without precious metal catalysts.
The method supports the construction of complex 2H-indazoles embedded within medium-sized rings, potentially benefiting bioactive compounds.

Cite This Study

Jiang et al. (2025) studied this question.

synapsesocial.com/papers/692b94341d383f2b2a3785ff https://doi.org/10.1002/adsc.70247

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