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November 30, 2025AnimalsOpen Access

Divergent Regulation of Mammary Lipogenesis by trans-10, cis-12 and cis-9, trans-11 CLA Isomers Is Determined by Receptor-Specific Signaling

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Authors

SCSiwen ChengAZAng ZhaoXLXueyan Lin

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Overview

Observational analysis shows divergent effects of trans-10, cis-12 and cis-9, trans-11 CLA on lipid synthesis in goat epithelial cells, suggesting targeted nutritional strategies in dairy production.

Key Points

  • t10c12-CLA significantly suppressed SREBP-1 and PGC-1α, impairing mitochondrial activity and causing lipid droplet accumulation.
  • Transcriptomic analysis confirmed isomer-specific gene expression patterns, indicating the complex role of CLA in lipid metabolism.
  • GPR40 inhibition reversed the effects of t10c12-CLA, demonstrating its role in antilipogenic signaling.
  • These findings highlight the potential for CLA isomers to inform precision nutritional strategies in dairy production.

Cite This Study

Cheng et al. (2025) studied this question.

synapsesocial.com/papers/692b94581d383f2b2a378fa3https://doi.org/10.3390/ani15233418
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Divergent Regulation of Mammary Lipogenesis by trans-10, cis-12 and cis-9, trans-11 CLA Isomers Is Determined by Receptor-Specific Signaling2025
  2. 2Isomer-Specific Effects of cis-9,trans-11- and trans-10,cis-12-CLA on Immune Regulation in Ruminal Epithelial Cells2021 · 6 citations
  3. 3Effects of Linoleic Acid and Its Trans-10 Biohydrogenation Intermediates (Trans-10,Cis-12 Conjugated Linoleic Acid and Trans-10 18:1) on Lipogenic Gene Expression and Δ9-Desaturation Indices in Bovine Intramuscular Adipocytes2026
  4. 4Effect of diets supplemented with different conjugated linoleic acid (CLA) isomers on protein expression in C57/BL6 mice2016 · 8 citations
  5. 5The Effects of Supplemented Conjugated Linoleic Acid on Lipid Metabolism in Cattle2026