PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
November 30, 2025Nature CommunicationsOpen Access

Torsion is a dynamic regulator of DNA replication stalling and reactivation

View Full Paper
Ask AI
Bookmark
Share

Authors

XJXiaomeng JiaXGXiang GaoSZShuming Zhang

Discussion

Loading...

Member takes

Overview

Analysis uncovers helicase-DNAP synergy's role in maintaining fork integrity during replication, suggesting torsion impacts stalling and restart.

Key Points

  • Replication integrity is maintained through helicase-DNAP interactions under torsional stress.
  • The found replisome generates significant torque, approximately 22 pN·nm, highlighting its efficiency over E. coli RNA polymerase.
  • High-resolution assays tracked DNA rotation and stalling under torsion to elucidate replisome dynamics and stability.
  • The role of torsion in regulating replication processes underscores the importance of complex molecular interactions.

Cite This Study

Jia et al. (2025) studied this question.

synapsesocial.com/papers/692b94581d383f2b2a378fbdhttps://doi.org/10.1038/s41467-025-65567-5
View Full Paper
Ask AI
Bookmark
Share