November 30, 2025Frontiers in ImmunologyOpen Access

Inflammation-driven mechanisms in endometrial cancer: pathways from inflammatory microenvironment remodeling to immune escape

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Discussion

This analysis demonstrates immune evasion mechanisms in endometrial cancer, suggesting interventions to improve immunotherapy efficacy.

Immune evasion exacerbated tumor growth in endometrial cancer through regulatory T cells and immune checkpoint molecules.
Key processes involve inflammatory microenvironment remodeling, particularly extracellular matrix alterations and angiogenesis.
Single-cell analysis has identified potential molecular patterns linked to therapeutic resistance in endometrial cancer.
Insights into immune dynamics and checkpoint modulation might enable personalized immunotherapy approaches for better outcomes.

Tan et al. (2025) studied this question.

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