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This review aims to systematically examine the tumor immune microenvironment's composition and its impact on endometrial cancer treatment.

June 12, 2026MedComm – OncologyOpen Access

The Tumor Immune Microenvironment in Endometrial Cancer: Composition, Molecular Subtypes, and Therapeutic Implications

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This review analyzes the tumor immune microenvironment in endometrial cancer, revealing implications for therapy and future research.

This review aims to systematically examine the tumor immune microenvironment's composition and its impact on endometrial cancer treatment.
Analyzed immune cell populations and distinct molecular subtypes of endometrial cancer.
Explored mechanisms of immune suppression through pathways like PD-1/PD-L1.
Highlighted recent advances in therapeutic approaches including immune checkpoint blockades and adoptive cell therapies.
Identified key immune cell components such as tumor-associated macrophages and MDSCs that influence therapeutic response.
Demonstrated differences in immunogenicity among TIME subtypes affecting immunotherapy outcomes.
Evaluated current immunotherapies' strengths and limitations while suggesting new therapeutic targets for future precision oncology.

Ye et al. (2026) studied this question.

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