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November 30, 2025CancersOpen Access

MET Overexpression Is Associated with Superior Immunotherapy Benefit in Advanced Non-Small Cell Lung Cancer

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Authors

HLHui LiLHLingzhi HongPRPedro Rocha

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Overview

Observational analysis shows MET overexpression as a significant prognostic factor for improved survival in NSCLC, suggesting its role as a predictive marker for treatment efficacy.

Key Points

  • Patients with MET overexpression showed better progression-free survival, indicating the potential of targeted therapies.
  • Logistic regression identified adenocarcinoma histology and PD-L1 expression as associated factors with MET overexpression in a NSCLC cohort.
  • Analysis used the Akaike Information Criterion for the statistical modeling of overall survival metrics in advanced lung cancer.
  • Findings highlight that MET expression could guide treatment strategies that combine MET-targeted agents with immune checkpoint inhibitors.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/692b9d8d1d383f2b2a379947https://doi.org/10.3390/cancers17233801
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1MET Overexpression Is Associated with Superior Immunotherapy Benefit in Advanced Non-Small Cell Lung Cancer2025
  2. 2Association of MET overexpression with patient outcomes in <i>EGFR</i> -mutant lung adenocarcinoma treated with first-line osimertinib.2026
  3. 3MET expression by immunohistochemistry as a biomarker in pancreatic neuroendocrine tumours2026
  4. 4Prevalence, molecular characterization, and prognosis of c-Met protein overexpression in a real-world cohort of patients with non-squamous non-small cell lung cancer2025
  5. 5Unraveling the Significance of MET Focal Amplification in Lung Cancer: Integrative NGS, FISH, and IHC Investigation2024 · 18 citations