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November 30, 2025Advanced Functional MaterialsOpen Access

A 3D Biofabricated Disease Model Mimicking the Brain Extracellular Matrix Suitable to Characterize Intrinsic Neuronal Network Alterations in the Presence of a Breast Tumor Disseminated to the Brain

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Implication

Biofabricated model demonstrates that breast tumor interactions in the brain alter neuronal network dynamics, suggesting potential treatment approaches.

Key Points

  • Neuronal network activity significantly increases in the presence of breast tumor cells.
  • MDA-MB-361 interacts extensively with the extracellular matrix, particularly collagen type IV.
  • The 3D cellular model mimics the brain extracellular matrix to study tumor microenvironment effects.
  • Findings may enable better understanding of brain metastasis mechanisms in breast cancer patients.

Cite This Study

A 2025 study studied this question.

synapsesocial.com/papers/692b9d9a1d383f2b2a379f33https://doi.org/10.1002/adfm.202515220
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