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February 23, 2026Advanced Functional Materials

A 3D Biofabricated Disease Model Mimicking the Brain Extracellular Matrix Suitable to Characterize Intrinsic Neuronal Network Alterations in the Presence of a Breast Tumor Disseminated to the Brain (Adv. Funct. Mater. 15/2026)

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Authors

ETEsra TürkerMMMateo S. Andrade MierJFJessica Faber

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Overview

3D biofabricated model reveals breast tumor increases neuronal firing through gap junctions in brain tissue.

Key Points

  • Investigate how breast tumors influence neuronal activity using a 3D biofabricated brain model.
  • Developed a 3D biofabricated model mimicking the brain extracellular matrix.
  • Evaluated interactions between metastatic breast tumor cells, neurons, and astrocytes.
  • Measured neuronal firing capacity in the presence of tumor cells.
  • Breast tumor cells increased the firing capacity of neurons.
  • Tumor cells created pseudosynaptic contacts with neurons.
  • Gap junctions formed between tumor cells and astrocytes.

Cite This Study

Türker et al. (2026) studied this question.

synapsesocial.com/papers/699ba07072792ae9fd87010ahttps://doi.org/10.1002/adfm.74287
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A 3D Biofabricated Disease Model Mimicking the Brain Extracellular Matrix Suitable to Characterize Intrinsic Neuronal Network Alterations in the Presence of a Breast Tumor Disseminated to the Brain2025
  2. 2Breast Tumor Cell Survival and Morphology in a Brain‐like Extracellular Matrix Depends on Matrix Composition and Mechanical Properties2024 · 10 citations
  3. 3Scaffold-free 3D-cell co-culture model system for the study of metastatic cancer in the brain TME2026
  4. 4A biofabricated 3D cancer-stroma tumor microenvironment model2025
  5. 5Abstract 768: Modeling the triple-negative breast cancer extracellular matrix in a 3d tumor scaffold.2026