November 30, 2025RMD OpenOpen Access

Synovial fibroblast activation occurs before the onset of rheumatoid arthritis and influences the risk of developing disease

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Fibroblast activation protein inhibitor is linked to clinical disease onset in rheumatoid arthritis.
Total lesion FAPI-uptake was a significant predictor of rheumatoid arthritis development (HR 4.58).
Positron emission tomography-CT was performed on individuals with anti-citrullinated protein antibodies to assess risk.
Findings highlight the importance of early detection and risk assessment for clinical rheumatoid arthritis.

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Implication

Observational analysis shows fibroblast activation links to clinical disease in individuals with rheumatoid arthritis risk, suggesting pet-ct could enhance risk assessments.

Cite This Study

Atzinger et al. (2025) studied this question.

synapsesocial.com/papers/692b9da91d383f2b2a37a402 https://doi.org/10.1136/rmdopen-2025-005775

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Implication

Observational analysis shows fibroblast activation links to clinical disease in individuals with rheumatoid arthritis risk, suggesting pet-ct could enhance risk assessments.

Synovial fibroblast activation occurs before the onset of rheumatoid arthritis and influences the risk of developing disease

Key Points

Discussion

Implication

Cite This Study

Synovial fibroblast activation occurs before the onset of rheumatoid arthritis and influences the risk of developing disease

Key Points

Discussion

Implication

Cite This Study

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