What question did this study set out to answer?

The research aims to evaluate fibroblast activation in psoriasis patients and its correlation with the risk of developing psoriatic arthritis.

March 25, 2026RMD OpenOpen Access

Increased synovial and entheseal fibroblast activation detected by ⁶⁸ Ga-FAPI-PET/CT is associated with the development of psoriatic arthritis in psoriasis patients with arthralgia

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The research aims to evaluate fibroblast activation in psoriasis patients and its correlation with the risk of developing psoriatic arthritis.
Psoriasis patients with joint pain underwent 68 Ga-FAPI-PET/CT imaging.
Fibroblast activation was identified at 71 articular sites with specific criteria.
Clinical and ultrasound findings were analyzed for associations.
Survival analyses were performed to assess the risk of progression to psoriatic arthritis.
82% of evaluated patients were positive for fibroblast activation.
FAPI-positive patients had significantly higher body mass index and disease activity scores.
Fibroblast activation frequently occurred in large joints and was associated with low-grade synovial hyperplasia and concomitant osteoarthritis.
FAPI-positive patients had a sevenfold increased risk of progressing to psoriatic arthritis compared to FAPI-negative patients.

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Implication

Clinical and imaging findings associate fibroblast activation with psoriatic arthritis risk in psoriasis patients with joint pain, indicating significant implications.

Cite This Study

Corte et al. (2026) studied this question.

synapsesocial.com/papers/69c37b11b34aaaeb1a67d164 https://doi.org/10.1136/rmdopen-2025-006567

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Implication

Clinical and imaging findings associate fibroblast activation with psoriatic arthritis risk in psoriasis patients with joint pain, indicating significant implications.

Increased synovial and entheseal fibroblast activation detected by ⁶⁸ Ga-FAPI-PET/CT is associated with the development of psoriatic arthritis in psoriasis patients with arthralgia

Key Points

Discussion

Implication

Cite This Study

Increased synovial and entheseal fibroblast activation detected by ⁶⁸ Ga-FAPI-PET/CT is associated with the development of psoriatic arthritis in psoriasis patients with arthralgia

Key Points

Discussion

Implication

Cite This Study

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