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November 30, 2025Food FrontiersOpen Access

Molecular Mechanism of Mulberrin Regulating Lipid Metabolism Homeostasis Based on the Gut–Liver Axis Fiaf/AMPK Signaling Pathway

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Authors

QLQian LiDPDaorui PangELErna Li

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Overview

Findings demonstrate that mulberrin influences lipid metabolism through Fiaf and AMPK pathways in hyperlipidemic mice, suggesting its potential as a hypolipidemic agent.

Key Points

  • Lipid metabolism improved significantly, reducing key metabolic markers in treatment groups.
  • Mulberrin showed strong activity with an IC50 of 2.21 µg/mL in regulating HMGCR activity.
  • Experimental analysis confirmed modulation of gut microbiota, particularly with increased Lactobacillus and decreased Lachnospiraceae.
  • These results may enable the development of new functional foods targeting lipid metabolism disorders.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/692b9da91d383f2b2a37a643https://doi.org/10.1002/fft2.70197
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