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November 30, 2025Journal of Personalized MedicineOpen Access

The Heterogeneous Interplay Between Metabolism and Mitochondrial Activity in Colorectal Cancer

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Authors

CDChristophe DesterkeYFYuanji FuJGJorge Mata Garrido

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Overview

Observational analysis highlights metabolic activity in colorectal cancer, suggesting TP53 status as a predictive biomarker.

Key Points

  • Single-cell RNA-sequencing revealed varied metabolism in colorectal cancer tumors based on mutation status, with implications for therapy.
  • The analysis significantly associates immune checkpoint blockade therapy with metabolic status in colorectal cancer, particularly in TP53 mutated cases.
  • Machine learning identified a mixed metabolism score predictive of BRAF-V600E mutation in colorectal cancer, emphasizing the metabolic-therapeutic link.
  • Findings suggest the role of metabolism as a predictive biomarker for tailored therapeutic strategies in colorectal cancer patients.

Cite This Study

Desterke et al. (2025) studied this question.

synapsesocial.com/papers/692b9da91d383f2b2a37a676https://doi.org/10.3390/jpm15120571
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mitochondrial DNA (mtDNA) expression as used to define metabolic and immune states in colorectal cancer (CRC).2026
  2. 2Identification of Methionine Metabolism‐Driven Heterogeneous Subtypes in Colorectal Cancer and Their Associated Immune Microenvironment2026
  3. 3The integration of single-cell and metabolomics reveals the increase of oxidative phosphorylation during the liver metastasis of colorectal cancer2025 · 5 citations
  4. 4A mitochondrial lipid metabolism–related gene signature predicts prognosis and immune landscape in colorectal cancer2025
  5. 5Multiomics analyses of human colorectal cancer reveal changes in mitochondrial metabolism associated with chemotherapy resistance2025