December 2, 2025Environmental HealthOpen Access

Cumulative childhood lead exposure estimation and school-age IQ in a prospective birth cohort

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Cumulative childhood lead exposure negatively associates with school-age IQ, suggesting a complex interaction with cognitive development.
In unadjusted analyses, children with key maternal factors showed lower IQ linked to lead exposure, emphasizing the need for adjustment.
Research employed regression calibration for accurate estimation in a prospective birth cohort, focusing on childhood lead exposure data.
Findings indicate maternal factors can confound associations between the exposure and cognitive outcomes, emphasizing future research needs.

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Regression calibration reveals lead exposure negatively impacts IQ in children, indicating maternal factors may confound results.

Xu et al. (2025) studied this question.

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