December 2, 2025Translational PsychiatryOpen Access

Abnormal cortical topographic patterns associated with auditory verbal hallucination in first-episode schizophrenia

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Auditory verbal hallucination is linked to specific neuroimaging patterns in first-episode schizophrenia, highlighting brain network alterations.
Analysis used resting-state functional MRI and compared 104 schizophrenia patients to 90 healthy controls to explore functional connectivity.
The topographic changes in AVH are associated with the molecular basis related to neurotransmitter systems, including noradrenaline and acetylcholine.
Findings indicate that disruptions in cortical networks play a critical role in the development of auditory verbal hallucinations.

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Neuroimaging reveals altered brain topography in first-episode schizophrenia, indicating AVH's molecular basis.

Lui et al. (2025) studied this question.

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