What does this research mean for the field?

Medicated individuals with persistent auditory verbal hallucinations exhibit increased functional connectivity in default mode network hubs and frontotemporal regions, as well as targeted cortical thinning, compared to healthy controls, though these differences cannot be definitively isolated from underlying psychiatric disorders. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To investigate multimodal structural and functional MRI features associated with persistent auditory verbal hallucinations in individuals with psychotic disorders compared to healthy controls.

August 20, 2026TomographyOpen Access

Candidate Multimodal MRI Markers of Persistent Auditory Verbal Hallucinations: A Controlled Pilot Study

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FAFaten M. Aldhafeeri

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Implication

Controlled study reveals altered default mode connectivity and localized cortical thinning in psychiatric patients with persistent auditory verbal hallucinations, highlighting potential candidate...

Key Points

To investigate multimodal structural and functional MRI features associated with persistent auditory verbal hallucinations in individuals with psychotic disorders compared to healthy controls.
Enrolled 14 psychiatric patients with persistent auditory verbal hallucinations (mean hallucination phase 3.1 ± 1.6 years; illness duration 12.4 ± 4.8 years) and 15 age- and sex-matched healthy controls.
Evaluated resting-state functional connectivity via independent component analysis, cortical thickness via BrainVoyager QX, and white matter microstructure using diffusion tensor imaging.
Applied false discovery rate and Monte Carlo cluster-extent corrections for functional and structural analyses, alongside TFCE (FWE-corrected p < 0.05) for diffusion metrics.
Participants with auditory verbal hallucinations exhibited significantly increased functional connectivity within default mode network hubs (precuneus, inferior frontal, and parahippocampal gyri) and superior temporal regions.
Whole-brain cortical thickness and diffusion tensor imaging analyses showed no statistically significant group differences surviving whole-brain permutation correction (TFCE, FWE-corrected p < 0.05).
Exploratory region-of-interest analyses of six previously implicated regions revealed significant cortical thinning in participants with hallucinations relative to controls following FDR correction.

Cite This Study

Faten M. Aldhafeeri (2026) studied this question.

synapsesocial.com/papers/6a86b5da8a91293e6a1cd68f https://doi.org/10.3390/tomography12080115

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Implication

Controlled study reveals altered default mode connectivity and localized cortical thinning in psychiatric patients with persistent auditory verbal hallucinations, highlighting potential candidate...

Candidate Multimodal MRI Markers of Persistent Auditory Verbal Hallucinations: A Controlled Pilot Study

Discussion

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Implication

Key Points

Cite This Study

Candidate Multimodal MRI Markers of Persistent Auditory Verbal Hallucinations: A Controlled Pilot Study

Discussion

Member takes

Implication

Key Points

Cite This Study

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